PHD2/EGLN1 Polyclonal Antibody
- SKU:
- CAB1151
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | PHD2/EGLN1 Polyclonal Antibody |
| Product Code: | CAB1151 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | WB 1:500-1:2000, IHC-P 1:50-1:100, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | OVCAR8, COS-7, U2OS, SH-SY5Y, HeLa |
| Cellular Location: | Cytoplasm, Nucleus |
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-426 of human PHD2/EGLN1 (NP_071334.1). |
| Sequence: | MANDS GGPGG PSPSE RDRQY CELCG KMENL LRCSR CRSSF YCCKE HQRQD WKKHK LVCQG SEGAL GHGVG PHQHS GPAPP AAVPP PRAGA REPRK AAARR DNASG DAAKG KVKAK PPADP AAAAS PCRAA AGGQG SAVAA EAEPG KEEPP ARSSL FQEKA NLYPP SNTPG DALSP GGGLR PNGQT KPLPA LKLAL EYIVP CMNKH GICVV DDFLG KETGQ QIGDE VRALH DTGKF TDGQL VSQKS DSSKD IRGDK ITWIE GKEPG CETIG LLMSS MDDLI RHCNG KLGSY KINGR TKAMV ACYPG NGTGY VRHVD NPNGD GRCVT CIYYL NKDWD AKVSG GILRI FPEGK AQFAD IEPKF DRLLF FWSDR RNPHE VQPAY ATRYA ITVWY FDADE RARAK VKYLT GEKGV RVELN KPSDS VGKDV F |
| Synonyms: | HPH2, PHD2, SM20, ECYT3, HALAH, HPH-2, HIFPH2, ZMYND6, C1orf12, HIF-PH2 |
| Calculated MW: | 46kDa |
| Observed MW: | 45kDa |
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