PGPEP1 Antibody (PACO11202)
- SKU:
- PACO11202
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PGPEP1 Antibody (PACO11202) |
| Antibody SKU: | PACO11202 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human PGPEP1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | pyroglutamyl-peptidase I;PGPEP1;FLJ20208;MGC10812;PGP;PGP-I;PGPI;Pcp ; |
| UniProt Protein Function: | PGPEP1: Removes 5-oxoproline from various penultimate amino acid residues except L-proline. Belongs to the peptidase C15 family.Protein type: Protease; EC 3.4.19.3Chromosomal Location of Human Ortholog: 19p13.11Cellular Component: cytosolBiological Process: proteolysis |
| UniProt Protein Details: | |
| NCBI Summary: | The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q9NXJ5 |
| NCBI GenInfo Identifier: | 14548183 |
| NCBI Gene ID: | 54858 |
| NCBI Accession: | Q9NXJ5.1 |
| UniProt Secondary Accession: | Q9NXJ5,Q8IVT1, A8K1Q3 |
| UniProt Related Accession: | Q9NXJ5 |
| Molecular Weight: | 14,639 Da |
| NCBI Full Name: | Pyroglutamyl-peptidase 1 |
| NCBI Synonym Full Names: | pyroglutamyl-peptidase I |
| NCBI Official Symbol: | PGPEP1 |
| NCBI Official Synonym Symbols: | PGI; PGP; Pcp; PGPI; PAP-I; PGP-I |
| NCBI Protein Information: | pyroglutamyl-peptidase 1 |
| UniProt Protein Name: | Pyroglutamyl-peptidase 1 |
| UniProt Synonym Protein Names: | 5-oxoprolyl-peptidase; Pyroglutamyl aminopeptidase I; PAP-I; Pyroglutamyl-peptidase I; PGP-I; Pyrrolidone-carboxylate peptidase |
| Protein Family: | Pyroglutamyl-peptidase |
| UniProt Gene Name: | PGPEP1 |
| UniProt Entry Name: | PGPI_HUMAN |
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