PERK Monoclonal Antibody
- SKU:
- CAB21255
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | PERK Monoclonal Antibody |
| Product Code: | CAB21255 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC52369 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | 293T, K-562, NIH/3T3, PC-12 |
| Cellular Location: | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 580-720 of human PERK (NP_004827.4). |
| Sequence: | IKNSG YISRY LTDFE PIQCL GRGGF GVVFE AKNKV DDCNY AIKRI RLPNR ELARE KVMRE VKALA KLEHP GIVRY FNAWL EAPPE KWQEK MDEIW LKDES TDWPL SSPSP MDAPS VKIRR MDPFA TKEHI EIIAP SPQRS R |
| Synonyms: | PEK, WRS, PERK |
| Calculated MW: | 125kDa |
| Observed MW: | 140kDa |
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