Pepsinogen II (PG II) Monoclonal Antibody (CAB22282)
- SKU:
- CAB22282
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | Pepsinogen II (PG II) Monoclonal Antibody |
| Product Code: | CAB22282 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57717 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Secreted |
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-388 of human Pepsinogen II (PG II) (NP_002621.1). |
| Sequence: | MKWMV VVLVC LQLLE AAVVK VPLKK FKSIR ETMKE KGLLG EFLRT HKYDP AWKYR FGDLS VTYEP MAYMD AAYFG EISIG TPPQN FLVLF DTGSS NLWVP SVYCQ SQACT SHSRF NPSES STYST NGQTF SLQYG SGSLT GFFGY DTLTV QSIQV PNQEF GLSEN EPGTN FVYAQ FDGIM GLAYP ALSVD EATTA MQGMV QEGAL TSPVF SVYLS NQQGS SGGAV VFGGV DSSLY TGQIY WAPVT QELYW QIGIE EFLIG GQASG WCSEG CQAIV DTGTS LLTVP QQYMS ALLQA TGAQE DEYGQ FLVNC NSIQN LPSLT FIING VEFPL PPSSY ILSNN GYCTV GVEPT YLSSQ NGQPL WILGD VFLRS YYSVY DLGNN RVGFA TAA |
| Synonyms: | PEPC, PGII |
| Calculated MW: | 42kDa |
| Observed MW: | Refer to figures |
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