PEMT Antibody (PACO47582)
- SKU:
- PACO47582
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PEMT Antibody (PACO47582) |
| Antibody SKU: | PACO47582 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Phosphatidylethanolamine N-methyltransferase protein (2-49AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: SH-SY5Y whole cell lysate. All lanes: PEMT antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 23, 26, 25 kDa. Observed band size: 23 kDa.. |
 | Immunofluorescent analysis of A549 cells using PACO47582 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). |
| Synonyms: | Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (PEMT2) (Phospholipid methyltransferase) (PLMT), PEMT, PEMPT PNMT |
| UniProt Protein Function: | PEMT iso2: Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). Belongs to the PEMT/PEM2 methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - glycerophospholipid; Endoplasmic reticulum; Membrane protein, multi-pass; Mitochondrial; Methyltransferase; Membrane protein, integral; EC 2.1.1.71; EC 2.1.1.17Chromosomal Location of Human Ortholog: 17p11.2Cellular Component: endoplasmic reticulum membrane; mitochondrial membrane; integral to membraneMolecular Function: phosphatidyl-N-methylethanolamine N-methyltransferase activity; phosphatidylethanolamine N-methyltransferase activityBiological Process: methylation; cell proliferation; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine biosynthetic process; lipid metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012] |
| UniProt Code: | Q9UBM1 |
| NCBI GenInfo Identifier: | 388890237 |
| NCBI Gene ID: | 10400 |
| NCBI Accession: | NP_001254481.1 |
| UniProt Secondary Accession: | Q9UBM1,Q6IAQ5, Q86VL3, Q9BW86, Q9UHY6, Q9Y6V9, A8MZ66 B4DY41, D3DXC3 |
| UniProt Related Accession: | Q9UBM1 |
| Molecular Weight: | 22,134 Da |
| NCBI Full Name: | phosphatidylethanolamine N-methyltransferase isoform 3 |
| NCBI Synonym Full Names: | phosphatidylethanolamine N-methyltransferase |
| NCBI Official Symbol: | PEMT |
| NCBI Official Synonym Symbols: | PNMT; PEAMT; PEMPT; PEMT2 |
| NCBI Protein Information: | phosphatidylethanolamine N-methyltransferase |
| UniProt Protein Name: | Phosphatidylethanolamine N-methyltransferase |
| UniProt Synonym Protein Names: | PEMT2 |
| Protein Family: | PEMT/PEM2 methyltransferase family protein |
| UniProt Gene Name: | PEMT |
| UniProt Entry Name: | PEMT_HUMAN |
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