PEDF PAT13D9AT Monoclonal Antibody [PAT13D9AT] (CPAB0088)
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![PEDF PAT13D9AT Monoclonal Antibody [PAT13D9AT] (CPAB0088)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58316/63498/pedf-pat13d9at-monoclonal-antibody-pat13d9at-cpab0088__82417__83237.1706534969.jpg?c=1 "PEDF PAT13D9AT Monoclonal Antibody [PAT13D9AT] (CPAB0088)")
- SKU:
- CPAB0088
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- PAT13D9AT
- Applications:
- WB
- Applications:
- ELISA
![PEDF PAT13D9AT Monoclonal Antibody [PAT13D9AT] (CPAB0088)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58316/63498/pedf-pat13d9at-monoclonal-antibody-pat13d9at-cpab0088__82417__83237.1706534969.jpg?c=1&imbypass=on "PEDF PAT13D9AT Monoclonal Antibody [PAT13D9AT] (CPAB0088)")
Description
system_update_alt Datasheet
| Product Name: | PEDF PAT13D9AT Antibody |
| Product Sku: | CPAB0088 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human PEDF mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PEDF protein 2-418 amino acids purified from Ecoli. |
| Clone: | PAT13D9AT. |
| Reactivity: | Human |
| Applications: | Western Blot, ELISA |
| Purification Method: | PEDF antibody was purified by protein-A affinity chromatography. |
| Isotype: | IgG1 |
| Background: | PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuro-protective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF in addition has the potential to be functional in the treatment of various angiogenesis-related diseases including a number of cancers. |
| Synonyms: | Pigment epithelium-derived factor,PEDF, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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