PEAK1 Antibody (PACO60372)
- SKU:
- PACO60372
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PEAK1 Antibody (PACO60372) |
| Antibody SKU: | PACO60372 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Pseudopodium-enriched atypical kinase 1 protein (715-881AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO60372 diluted at 1:200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskeleton-associated proteins MAPK1/ERK and PXN. |
| Synonyms: | Pseudopodium-enriched atypical kinase 1 (EC 2.7.10.2) (Sugen kinase 269) (Tyrosine-protein kinase SgK269), PEAK1, KIAA2002 |
| UniProt Protein Function: | PEAK1: a cytoskeleton-associated non-receptor tyrosine kinase that localizes to focal adhesions and actin filaments. Operates downstream of integrin and epidermal growth factor receptors, regulating the P130Cas-Crk-PXN and MAPK signaling. In the late stages of EGF signaling, SGK269 mediates Shc1 protein interactions involved in and cell spreading, migration, and morphogenesis. Amplified in a large fraction of colon cancer. Influences anchorage-independent growth and tumor progression in mice.Protein type: EC 2.7.10.2; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; NKF3 familyChromosomal Location of Human Ortholog: 15q24.3Cellular Component: actin cytoskeleton; cytoplasm; focal adhesion; nucleoplasm; plasma membraneMolecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; protein bindingBiological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q9H792 |
| NCBI GenInfo Identifier: | 223634730 |
| NCBI Gene ID: | 79834 |
| NCBI Accession: | Q9H792.4 |
| UniProt Secondary Accession: | Q9H792,Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7 |
| UniProt Related Accession: | Q9H792 |
| Molecular Weight: | |
| NCBI Full Name: | Pseudopodium-enriched atypical kinase 1 |
| NCBI Synonym Full Names: | pseudopodium enriched atypical kinase 1 |
| NCBI Official Symbol: | PEAK1 |
| NCBI Official Synonym Symbols: | SGK269 |
| NCBI Protein Information: | pseudopodium-enriched atypical kinase 1 |
| UniProt Protein Name: | Pseudopodium-enriched atypical kinase 1 |
| UniProt Synonym Protein Names: | Sugen kinase 269; Tyrosine-protein kinase SgK269 |
| Protein Family: | Pseudopodium-enriched atypical kinase |
| UniProt Gene Name: | PEAK1 |
| UniProt Entry Name: | PEAK1_HUMAN |
| Antibodies |
| PEAK1 Antibody (PACO05378) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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