Description
| Product Name: | PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL2257) |
| Product Code: | AGEL2257 |
| Clone No: | 29F.1A12 |
| Synonyms: | PD-1, Programmed Death-1 |
| Reactivity: | Mouse |
| Host Species: | Rat |
| Applications: | FCM |
| Isotype: | Rat IgG2a, κ |
| Isotype Control: | PE/Cyanine7 Rat IgG2a, κ Isotype Control [2A3] (AGEL2660) |
| Conjugation: | PE/Cyanine7 |
| Form: | Liquid |
| Fluorescent Label: | PE/Cyanine7 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 775 nm (e.g., a 780/60 nm bandpass filter). |
| Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume]. |
| Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Swissprot: | Q02242 |
| Stability & Storage: | Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Shipping: | Biological ice pack at 4°C |
CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.
](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/12580/16632/mouse-cd279pd-1-monoclonal-antibody-pe-conjugated-29f.1a12agel1633__81728__46717.1706270071.jpg?c=1 "Mouse CD279/PD-1 Monoclonal Antibody (PE Conjugated) [29F.1A12](AGEL1633)")
](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/590x590/products/12575/16627/mouse-cd279pd-1-monoclonal-antibody-pe-conjugated-29f.1a12agel1628__38226__53394.1706270069.jpg?c=1 "Mouse CD279/PD-1 Monoclonal Antibody (PE Conjugated) [29F.1A12](AGEL1628)")