PE/Cyanine7 Anti-Mouse CD200 Antibody [OX-90] (AGEL2761)
- SKU:
- AGEL2761
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Mouse
- Host Species:
- Rat
- Isotype:
- Rat IgG2a, κ
- Clone:
- OX-90
- Conjugation:
- PE/Cyanine7
Description
| Product Name: | PE/Cyanine7 Anti-Mouse CD200 Antibody [OX-90] (AGEL2761) |
| Product Code: | AGEL2761 |
| Clone No: | OX-90 |
| Synonyms: | OX-2 membrane glycoprotein,OX-2, MRC |
| Reactivity: | Mouse |
| Host Species: | Rat |
| Applications: | FCM |
| Isotype: | Rat IgG2a, κ |
| Isotype Control: | PE/Cyanine7 Rat IgG2a, κ Isotype Control [2A3] (AGEL2660) |
| Conjugation: | PE/Cyanine7 |
| Form: | Liquid |
| Fluorescent Label: | PE/Cyanine7 is designed to be excited by the Blue (488 nm), Green (532 nm) and yellow-green (561 nm) lasers and detected using an optical filter centered near 775 nm (e.g., a 780/60 nm bandpass filter). |
| Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume]. |
| Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Swissprot: | O54901 |
| Stability & Storage: | Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Shipping: | Biological ice pack at 4°C |
CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R). The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.
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