PE Anti-Mouse FcεRIα Antibody [MAR-1]
- SKU:
- AGEL2315
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Mouse
- Host Species:
- Armenian Hamster
- Isotype:
- Armenian Hamster IgG
- Clone:
- MAR-1
- Conjugation:
- PE
Description
| Product Name: | PE Anti-Mouse FcεRIα Antibody [MAR-1] |
| Product Code: | AGEL2315 |
| Clone No: | MAR-1 |
| Synonyms: | High affinity immunoglobulin epsilon receptor subunit alpha,Fc-epsilon RI-alpha,FcERI,Fcer1a |
| Reactivity: | Mouse |
| Host Species: | Armenian Hamster |
| Applications: | FCM |
| Isotype: | Armenian Hamster IgG |
| Isotype Control: | PE Armenian Hamster IgG Isotype Control [PIP] (AGEL2701) |
| Conjugation: | PE |
| Form: | Liquid |
| Fluorescent Label: | PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter). |
| Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
| Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Swissprot: | P20489 |
| Stability & Storage: | Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Shipping: | Biological ice pack at 4°C |
FcεRIα is a transmembrane protein belonging to the Ig superfamily. FcεRIα forms a tetrameric complex with one β and two γ-subunits. The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcεRIα, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcεRIα subunit.
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