PDZRN3 Antibody (PACO48170)
- SKU:
- PACO48170
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PDZRN3 Antibody (PACO48170) |
| Antibody SKU: | PACO48170 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase PDZRN3 protein (133-404AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: PDZRN3 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 120, 39, 81 kDa. Observed band size: 120, 81, 39 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO48170 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO48170 at dilution of 1:100. |
| Background: | E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity). |
| Synonyms: | E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3), PDZRN3, KIAA1095 LNX3 SEMCAP3 |
| UniProt Protein Function: | PDZRN3: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligaseChromosomal Location of Human Ortholog: 3p13Cellular Component: neuromuscular junctionMolecular Function: ubiquitin-protein ligase activityBiological Process: neuromuscular junction development; protein ubiquitination |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q9UPQ7 |
| NCBI GenInfo Identifier: | 735367520 |
| NCBI Gene ID: | 23024 |
| NCBI Accession: | NP_001290068.1 |
| UniProt Secondary Accession: | Q9UPQ7,Q8N2N7, Q96CC2, Q9NSQ2, A7MCZ6 |
| UniProt Related Accession: | Q9UPQ7 |
| Molecular Weight: | 80,006 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase PDZRN3 isoform 2 |
| NCBI Synonym Full Names: | PDZ domain containing ring finger 3 |
| NCBI Official Symbol: | PDZRN3 |
| NCBI Official Synonym Symbols: | LNX3; SEMCAP3; SEMACAP3 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase PDZRN3 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase PDZRN3 |
| UniProt Synonym Protein Names: | Ligand of Numb protein X 3; PDZ domain-containing RING finger protein 3; Semaphorin cytoplasmic domain-associated protein 3; Protein SEMACAP3 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | PDZRN3 |
| UniProt Entry Name: | PZRN3_HUMAN |
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