PDPN Monoclonal Antibody [P5E2AT] (CPAB0527)
![PDPN Monoclonal Antibody [P5E2AT] (CPAB0527)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58748/63930/pdpn-monoclonal-antibody-p5e2at-cpab0527__11058__23083.1706535205.jpg?c=1 "PDPN Monoclonal Antibody [P5E2AT] (CPAB0527)")
- SKU:
- CPAB0527
![PDPN Monoclonal Antibody [P5E2AT] (CPAB0527)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58748/63930/pdpn-monoclonal-antibody-p5e2at-cpab0527__11058__23083.1706535205.jpg?c=1?imbypass=on "PDPN Monoclonal Antibody [P5E2AT] (CPAB0527)")
Description
system_update_alt Datasheet
| Product Name: | PDPN Antibody |
| Product Sku: | CPAB0527 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human PDPN mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PDPN amino acids 1-26 purified from Ecoli. |
| Clone: | P5E2AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA |
| Purification Method: | PDPN antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2b |
| Background: | Podoplanin is a small mucin-like type-1 transmembrane protein, typically expressed in various specialized cell types throughout the body. Podoplanin is a type-I integral membrane glycoprotein with diverse distribution in human tissues. PDPN physiological function is related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. PDPN is expressed in lymphatic progenitor cells and afterwards during mouse development in lymphatic endothelial cells. Podoplanin is a specific marker for lymph vessel endothelial cells. Over-expression of podoplanin significantly elevates endothelial cell adhesion, migration, and tube formation. Inhibition of Podoplanin expression decreases cell adhesion in human dermal lymphatic endothelial cells. Podoplanin is used as a specific marker for lymphatic endothelium in histopathology. Podoplanin expression is increased in nearly all human colon, rectum, and small intestine tumors. AGGRUS may serve as a diagnostic marker that distinguishes seminomas, the majority of which over express the protein, from embryonal carcinoma in testicular germ cell tumors. |
| Synonyms: | Podoplanin, Glycoprotein 36, PA2.26 antigen, T1A, GP36, GP40, Gp38, OTS8, T1A2, HT1A-1, PA2.26, T1-alpha, PDPN. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
Additional Information
Product Type: |
Antibody |
Antibody Type: |
Monoclonal Antibody |
Reactivity: |
Universal |
Host Species: |
Mouse |
Isotype: |
IgG2b |
Clone: |
P5E2AT |
Applications: |
WB |
Applications: |
ELISA |
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