PDLIM2 Antibody (PACO16850)
- SKU:
- PACO16850
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PDLIM2 Antibody (PACO16850) |
| Antibody SKU: | PACO16850 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:15-1:50 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human PDLIM2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: PACO16850(PDLIM2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16850(PDLIM2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| Synonyms: | PDZ and LIM domain 2 (mystique) |
| UniProt Protein Function: | PDLIM2: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin ligase; Cell adhesionChromosomal Location of Human Ortholog: 8p21.3Cellular Component: cortical actin cytoskeleton; focal adhesion; stress fiber; nucleus; actin cytoskeletonMolecular Function: zinc ion binding; filamin binding; muscle alpha-actinin binding; myosin heavy chain binding |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q96JY6 |
| NCBI GenInfo Identifier: | 38327612 |
| NCBI Gene ID: | 64236 |
| NCBI Accession: | NP_932159.1 |
| UniProt Secondary Accession: | Q96JY6,Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2, D3DSR5 J3KNH4 |
| UniProt Related Accession: | Q96JY6 |
| Molecular Weight: | |
| NCBI Full Name: | PDZ and LIM domain protein 2 isoform 3 |
| NCBI Synonym Full Names: | PDZ and LIM domain 2 (mystique) |
| NCBI Official Symbol: | PDLIM2 |
| NCBI Official Synonym Symbols: | SLIM; MYSTIQUE |
| NCBI Protein Information: | PDZ and LIM domain protein 2 |
| UniProt Protein Name: | PDZ and LIM domain protein 2 |
| UniProt Synonym Protein Names: | PDZ-LIM protein mystique |
| Protein Family: | PDZ and LIM domain protein |
| UniProt Gene Name: | PDLIM2 |
| UniProt Entry Name: | PDLI2_HUMAN |
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