Name: Pdia2 Antibody (PACO28874)
SKU: PACO28874
Availability: OutOfStock

Antibody Name:	Pdia2 Antibody (PACO28874)
Antibody SKU:	PACO28874
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:	Mouse, Human
Immunogen:	Recombinant Mouse Protein disulfide-isomerase A2 protein (21-527AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Western blot
All lanes: Pdia2 antibody at 10µg/ml + Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 59, 58 kDa
Observed band size: 59 kDa
.

Background:	Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins.
Synonyms:	Protein disulfide-isomerase A2 (EC 5.3.4.1) (PDIp), Pdia2, Pdip

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:	This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
UniProt Code:	D3Z6P0
NCBI GenInfo Identifier:	20070125
NCBI Gene ID:	5034
NCBI Accession:	NP_000909.2
UniProt Secondary Accession:	D3Z6P0,Q13087, D3Z6P0
UniProt Related Accession:	D3Z6P0,P07237
Molecular Weight:	58kDa
NCBI Full Name:	protein disulfide-isomerase
NCBI Synonym Full Names:	prolyl 4-hydroxylase subunit beta
NCBI Official Symbol:	P4HB
NCBI Official Synonym Symbols:	DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; CLCRP1; ERBA2L; P4Hbeta
NCBI Protein Information:	protein disulfide-isomerase
UniProt Protein Name:	Protein disulfide-isomerase
UniProt Synonym Protein Names:	Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55
Protein Family:
UniProt Gene Name:	P4HB
UniProt Entry Name:	PDIA1_HUMAN