PDGFR alpha Monoclonal Antibody
- SKU:
- CAB22220
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | PDGFR alpha Monoclonal Antibody |
| Product Code: | CAB22220 |
| Reactivity: | Human |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC56219 |
| Reactivity: | Human |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-524 of human PDGFR alpha (NP_006197.1). |
| Sequence: | QLSLP SILPN ENEKV VQLNS SFSLR CFGES EVSWQ YPMSE EESSD VEIRN EENNS GLFVT VLEVS SASAA HTGLY TCYYN HTQTE ENELE GRHIY IYVPD PDVAF VPLGM TDYLV IVEDD DSAII PCRTT DPETP VTLHN SEGVV PASYD SRQGF NGTFT VGPYI CEATV KGKKF QTIPF NVYAL KATSE LDLEM EALKT VYKSG ETIVV TCAVF NNEVV DLQWT YPGEV KGKGI TMLEE IKVPS IKLVY TLTVP EATVK DSGDY ECAAR QATRE VKEMK KVTIS VHEKG FIEIK PTFSQ LEAVN LHEVK HFVVE VRAYP PPRIS WLKNN LTLIE NLTEI TTDVE KIQEI RYRSK LKLIR AKEED SGHYT IVAQN EDAVK SYTFE LLTQV PSSIL DLVDD HHGST GGQTV RCTAE GTPLP DIEWM ICKDI KKCNN ETSWT ILANN VSNII TEIHS RDRST VEGRV TFAKV EETIA VRCLA KNLLG AENRE LKLVA PTLRS E |
| Synonyms: | CD140A, PDGFR2, PDGFR-2 |
| Calculated MW: | 123kDa |
| Observed MW: | Refer to figures |
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