Antibody Name:	Pdgfd Antibody (PACO46970)
Antibody SKU:	PACO46970
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200
Species Reactivity:	Mouse, Human
Immunogen:	Recombinant Mouse Platelet-derived growth factor D protein (24-370AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Immunofluorescent analysis of HepG2 cells using PACO46970 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
	Western Blot. Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate. All lanes: Pdgfd antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 43, 31 kDa. Observed band size: 43 kDa.

Background:

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix.

Synonyms:

Platelet-derived growth factor D (PDGF-D) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)], Pdgfd, Scdgfb

UniProt Protein Function:	PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Secreted; Oncoprotein; Secreted, signal peptide Cellular Component: extracellular region; extracellular space; membrane Molecular Function:growth factor activity; platelet-derived growth factor receptor binding Biological Process: cellular process; multicellular organismal development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; regulation of peptidyl-tyrosine phosphorylation
UniProt Code:	Q925I7
NCBI GenInfo Identifier:	27229137
NCBI Gene ID:	71785
NCBI Accession:	NP_082200.1
UniProt Secondary Accession:	Q925I7,Q3URF6, Q8K2L3, Q9D1L8,
UniProt Related Accession:	Q925I7
Molecular Weight:	56.2 kDa
NCBI Full Name:	platelet-derived growth factor D
NCBI Synonym Full Names:	platelet-derived growth factor, D polypeptide
NCBI Official Symbol:	Pdgfd
NCBI Official Synonym Symbols:	1110003I09Rik
NCBI Protein Information:	platelet-derived growth factor D
UniProt Protein Name:	Platelet-derived growth factor D
UniProt Synonym Protein Names:	Spinal cord-derived growth factor B; SCDGF-B
Protein Family:	Platelet-derived growth factor
UniProt Gene Name:	Pdgfd
UniProt Entry Name:	PDGFD_MOUSE