PDE6H Antibody (PACO35442)
- SKU:
- PACO35442
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PDE6H Antibody (PACO35442) |
| Antibody SKU: | PACO35442 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit γ protein (1-83AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO35442 diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. |
| Synonyms: | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit γ (GMP-PDE gamma) (EC 3.1.4.35), PDE6H |
| UniProt Protein Function: | Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q13956 |
| NCBI GenInfo Identifier: | 5453868 |
| NCBI Gene ID: | 5149 |
| NCBI Accession: | NP_006196 |
| UniProt Secondary Accession: | Q13956,Q52LY7 |
| UniProt Related Accession: | Q13956 |
| Molecular Weight: | 11.5 kDa (106aa) confirmed by MALDI-TOF |
| NCBI Full Name: | retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
| NCBI Synonym Full Names: | phosphodiesterase 6H |
| NCBI Official Symbol: | PDE6H |
| NCBI Official Synonym Symbols: | RCD3; ACHM6 |
| NCBI Protein Information: | retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
| UniProt Protein Name: | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma |
| UniProt Synonym Protein Names: | |
| Protein Family: | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase |
| UniProt Gene Name: | PDE6H |
| UniProt Entry Name: |
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