PDCL3 Antibody (PACO63891)
- SKU:
- PACO63891
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PDCL3 Antibody (PACO63891) |
| Antibody SKU: | PACO63891 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Phosducin-like protein 3 protein (1-239AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: A2780 whole cell lysate, 293 whole cell lysate, U251 whole cell lysate, MCF-7 whole cell lysate, PC-3 whole cell lysate. All lanes: PDCL3 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 28 kDa. Observed band size: 37 kDa. |
 | Immunofluorescence staining of HepG2 cells with PACO63891 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. |
| Synonyms: | Phosducin-like protein 3 (HTPHLP) (PhPL3) (Viral IAP-associated factor 1) (VIAF-1), PDCL3, PhLP2A VIAF1 |
| UniProt Protein Function: | PDCL3: Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination. Belongs to the phosducin family.Protein type: ApoptosisChromosomal Location of Human Ortholog: 2q11.2Cellular Component: cytoplasm; nucleusMolecular Function: protein binding; queuine tRNA-ribosyltransferase activityBiological Process: positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; queuosine biosynthetic process; regulation of peptidyl-tyrosine phosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H2J4 |
| NCBI GenInfo Identifier: | 50401164 |
| NCBI Gene ID: | 79031 |
| NCBI Accession: | Q9H2J4.1 |
| UniProt Secondary Accession: | Q9H2J4,Q53S68, B2RA00 |
| UniProt Related Accession: | Q9H2J4 |
| Molecular Weight: | 27,614 Da |
| NCBI Full Name: | Phosducin-like protein 3 |
| NCBI Synonym Full Names: | phosducin like 3 |
| NCBI Official Symbol: | PDCL3 |
| NCBI Official Synonym Symbols: | VIAF; PHLP3; VIAF1; HTPHLP; PHLP2A |
| NCBI Protein Information: | phosducin-like protein 3 |
| UniProt Protein Name: | Phosducin-like protein 3 |
| UniProt Synonym Protein Names: | HTPHLP; PhPL3; Viral IAP-associated factor 1; VIAF-1 |
| Protein Family: | Phosducin-like protein |
| UniProt Gene Name: | PDCL3 |
| UniProt Entry Name: | PDCL3_HUMAN |
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