PDCD4 Monoclonal Antibody [Pk4C1AT] (CPAB0523)
![PDCD4 Monoclonal Antibody [Pk4C1AT] (CPAB0523)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58744/63926/pdcd4-monoclonal-antibody-pk4c1at-cpab0523__31560__47054.1706535203.jpg?c=1 "PDCD4 Monoclonal Antibody [Pk4C1AT] (CPAB0523)")
- SKU:
- CPAB0523
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- Pk4C1AT
- Applications:
- WB
- Applications:
- ELISA
![PDCD4 Monoclonal Antibody [Pk4C1AT] (CPAB0523)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58744/63926/pdcd4-monoclonal-antibody-pk4c1at-cpab0523__31560__47054.1706535203.jpg?c=1&imbypass=on "PDCD4 Monoclonal Antibody [Pk4C1AT] (CPAB0523)")
Description
system_update_alt Datasheet
| Product Name: | PDCD4 Antibody |
| Product Sku: | CPAB0523 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human PDCD4 mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PDCD4 amino acids 1-469 purified from Ecoli. |
| Clone: | Pk4C1AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA |
| Purification Method: | PDCD4 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG1 |
| Background: | PDCD4 is restricted to the nucleus in proliferating cells. Expression of PDCD4 is modulated by cytokines in natural killer and T cells. PDCD4 takes part in apoptosis. PDCD4 is a translation inhibitor targeted for degradation during tumor promotion. PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. PDCD4 is swiftly phosphorylated by S6K1 kinase protein & afterwords degraded by ubiquitin ligase SCF in response to mitogens. PDCD4 in response to mitogens allows competent protein synthesis & cell growth. PDCD4 is a proapoptotic protein involved in TGF-beta1-induced apoptosis in human HCC cells, and a tumor suppressor in hepatocarcinogenesis. PDCD4 restraines tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription. |
| Synonyms: | Programmed cell death protein 4, Nuclear antigen H731-like, Neoplastic transformation inhibitor protein, Protein 197/15a, PDCD4, H731, MGC33046, MGC33047. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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