PD-L1/CD274 Polyclonal Antibody (CAB21443)
- SKU:
- CAB21443
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | PD-L1/CD274 Polyclonal Antibody |
| Product Code: | CAB21443 |
| Reactivity: | Human, Mouse |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | HepG2 |
| Cellular Location: | Cell membrane, Endomembrane system, Single-pass type I membrane protein |
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-290 of human PD-L1/CD274 (NP_054862.1). |
| Sequence: | LFNVT STLRI NTTTN EIFYC TFRRL DPEEN HTAEL VIPEL PLAHP PNERT HLVIL GAILL CLGVA LTFIF RLRKG RMMDV KKCGI QDTNS KKQSD THLEE T |
| Synonyms: | B7-H, B7H1, PDL1, PD-L1, hPD-L1, PDCD1L1, PDCD1LG1 |
| Calculated MW: | 33kDa |
| Observed MW: | 40kDa |
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