PCSK7 Antibody (PACO57916)
- SKU:
- PACO57916
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PCSK7 Antibody (PACO57916) |
| Antibody SKU: | PACO57916 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Proprotein convertase subtilisin/kexin type 7 protein (189-362AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO57916 diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Serine endoprotease that processes various proproteins by cleavage at paired basic amino acid, , recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway. |
| Synonyms: | Proprotein convertase subtilisin/kexin type 7 (EC 3.4.21) (Lymphoma proprotein convertase) (Prohormone convertase 7) (Proprotein convertase 7) (PC7) (Proprotein convertase 8) (PC8) (hPC8) (Subtilisin/kexin-like protease PC7), PCSK7, LPC PC7 PC8 SPC7 |
| UniProt Protein Function: | PCSK7: Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif. Belongs to the peptidase S8 family.Protein type: Protease; Membrane protein, integral; EC 3.4.21.-Chromosomal Location of Human Ortholog: 11q23-q24Cellular Component: integral to Golgi membraneMolecular Function: peptidase activity; serine-type endopeptidase activityBiological Process: protein processing |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q16549 |
| NCBI GenInfo Identifier: | 205830663 |
| NCBI Gene ID: | 9159 |
| NCBI Accession: | Q16549.2 |
| UniProt Secondary Accession: | Q16549,Q3C1X1, Q53GM4, Q96FK8, Q9UL57, B0YJ60 |
| UniProt Related Accession: | Q16549 |
| Molecular Weight: | 86,247 Da |
| NCBI Full Name: | Proprotein convertase subtilisin/kexin type 7 |
| NCBI Synonym Full Names: | proprotein convertase subtilisin/kexin type 7 |
| NCBI Official Symbol: | PCSK7 |
| NCBI Official Synonym Symbols: | LPC; PC7; PC8; SPC7 |
| NCBI Protein Information: | proprotein convertase subtilisin/kexin type 7 |
| UniProt Protein Name: | Proprotein convertase subtilisin/kexin type 7 |
| UniProt Synonym Protein Names: | Lymphoma proprotein convertase; Prohormone convertase 7; Proprotein convertase 7; PC7; Proprotein convertase 8; PC8; hPC8; Subtilisin/kexin-like protease PC7 |
| Protein Family: | Proprotein convertase subtilisin/kexin |
| UniProt Gene Name: | PCSK7 |
| UniProt Entry Name: | PCSK7_HUMAN |
| Antibodies |
| PCSK7 Antibody (PACO11115) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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