Pcsk2 Antibody (PACO53710)
- SKU:
- PACO53710
- Product Type:
- Antibody
- Reactivity:
- Rat
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Pcsk2 Antibody (PACO53710) |
| Antibody SKU: | PACO53710 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Rat, Human |
| Immunogen: | Recombinant Rat Neuroendocrine convertase 2 protein (109-637AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Jurkat whole cell lysate. All lanes: Pcsk1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 71 kDa. Observed band size: 71 kDa. |
| Background: | Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid, residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). |
| Synonyms: | Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2), Pcsk2, Nec-2 Nec2 Rpc2 |
| UniProt Protein Function: | PCSK2: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Belongs to the peptidase S8 family. Furin subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protease; EC 3.4.21.94Chromosomal Location of Human Ortholog: 20p11.2Cellular Component: extracellular space; transport vesicle; membrane; dendrite; perikaryonMolecular Function: protein binding; serine-type endopeptidase activity; protein complex bindingBiological Process: insulin processing; nervous system development; protein autoprocessing; cellular protein metabolic process; proteolysis |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014] |
| UniProt Code: | P28841 |
| NCBI GenInfo Identifier: | 13124785 |
| NCBI Gene ID: | 5126 |
| NCBI Accession: | P16519.2 |
| UniProt Secondary Accession: | P28841,P21661, P28841 |
| UniProt Related Accession: | P28841,P16519, AAB32656 |
| Molecular Weight: | |
| NCBI Full Name: | Neuroendocrine convertase 2 |
| NCBI Synonym Full Names: | proprotein convertase subtilisin/kexin type 2 |
| NCBI Official Symbol: | PCSK2 |
| NCBI Official Synonym Symbols: | PC2; NEC2; SPC2; NEC 2; NEC-2 |
| NCBI Protein Information: | neuroendocrine convertase 2; prohormone convertase 2; KEX2-like endoprotease 2 |
| UniProt Protein Name: | Neuroendocrine convertase 2 |
| UniProt Synonym Protein Names: | KEX2-like endoprotease 2; Prohormone convertase 2; Proprotein convertase 2; PC2 |
| Protein Family: | Putative envelope glycoprotein |
| UniProt Gene Name: | PCSK2 |
| UniProt Entry Name: | NEC2_HUMAN |
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