PCID2 Antibody (PACO52434)
- SKU:
- PACO52434
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PCID2 Antibody (PACO52434) |
| Antibody SKU: | PACO52434 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human PCI domain-containing protein 2 protein (2-250AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO52434 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO52434 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells. |
| Synonyms: | PCI domain-containing protein 2 (CSN12-like protein), PCID2 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a component of the TREX-2 complex (transcription and export complex 2), which regulates mRNA export from the nucleus. This protein regulates expression of Mad2 mitotic arrest deficient-like 1, a cell division checkpoint protein. This protein also interacts with and stabilizes Brca2 (breast cancer 2) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| UniProt Code: | Q5JVF3 |
| NCBI GenInfo Identifier: | 16741617 |
| NCBI Gene ID: | 55795 |
| NCBI Accession: | BC016614 |
| UniProt Secondary Accession: | Q5JVF3,Q3ZCX1, Q5TC57, Q5TC58, Q9H7K1, Q9HBZ7, Q9NUK6 Q9NVY1, Q9NW44, Q9NWH3 |
| UniProt Related Accession: | Q5JVF3 |
| Molecular Weight: | 52,100 Da |
| NCBI Full Name: | Homo sapiens PCI domain containing 2, mRNA |
| NCBI Synonym Full Names: | PCI domain containing 2 |
| NCBI Official Symbol: | PCID2 |
| NCBI Official Synonym Symbols: | F10 |
| NCBI Protein Information: | PCI domain-containing protein 2 |
| UniProt Protein Name: | |
| UniProt Synonym Protein Names: | |
| Protein Family: | PCI domain-containing protein |
| UniProt Gene Name: | |
| UniProt Entry Name: |
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