PCDHGB7 Antibody (PACO64455)
- SKU:
- PACO64455
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PCDHGB7 Antibody (PACO64455) |
| Antibody SKU: | PACO64455 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | IF:1:100-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protocadherin gamma-B7 protein (719-929AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Antigen Affinity purified & Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of SH-SY5Y cells with PACO64455 at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| Synonyms: | Protocadherin gamma-B7 (PCDH-gamma-B7), PCDHGB7 |
| UniProt Protein Function: | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5F8 |
| NCBI GenInfo Identifier: | 11128027 |
| NCBI Gene ID: | 56099 |
| NCBI Accession: | NP_061750.1 |
| UniProt Secondary Accession: | Q9Y5F8,Q9UN63 |
| UniProt Related Accession: | Q9Y5F8 |
| Molecular Weight: | 88,347 Da |
| NCBI Full Name: | protocadherin gamma-B7 isoform 1 |
| NCBI Synonym Full Names: | protocadherin gamma subfamily B, 7 |
| NCBI Official Symbol: | PCDHGB7 |
| NCBI Official Synonym Symbols: | ME6; PCDH-GAMMA-B7 |
| NCBI Protein Information: | protocadherin gamma-B7 |
| UniProt Protein Name: | Protocadherin gamma-B7 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHGB7 |
| UniProt Entry Name: |
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