Antibody Name:	PCDHB15 Antibody (PACO20192)
Antibody SKU:	PACO20192
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human PCDHB15

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20192(PCDHB15 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20192(PCDHB15 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene is a member of the protocadherin β gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The β cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections.

Synonyms:

protocadherin β 15

UniProt Protein Function:	PCDHB15: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneMolecular Function: calcium ion bindingBiological Process: nervous system development; cell adhesion; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:	This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9Y5E8
NCBI GenInfo Identifier:	13431379
NCBI Gene ID:	56121
NCBI Accession:	Q9Y5E8.1
UniProt Secondary Accession:	Q9Y5E8,Q8IUX5
UniProt Related Accession:	Q9Y5E8
Molecular Weight:	86,329 Da
NCBI Full Name:	Protocadherin beta-15
NCBI Synonym Full Names:	protocadherin beta 15
NCBI Official Symbol:	PCDHB15
NCBI Official Synonym Symbols:	PCDH-BETA15
NCBI Protein Information:	protocadherin beta-15
UniProt Protein Name:	Protocadherin beta-15
UniProt Synonym Protein Names:
Protein Family:	Protocadherin
UniProt Gene Name:	PCDHB15
UniProt Entry Name:	PCDBF_HUMAN