PCDHAC2 Antibody (PACO20186)
- SKU:
- PACO20186
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PCDHAC2 Antibody (PACO20186) |
| Antibody SKU: | PACO20186 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human PCDHAC2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20186(PCDHAC2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene is a member of the protocadherin α gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The α gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. |
| Synonyms: | protocadherin α subfamily C, 2 |
| UniProt Protein Function: | PCDHAC2: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneBiological Process: cell adhesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5I4 |
| NCBI GenInfo Identifier: | 13878435 |
| NCBI Gene ID: | 56134 |
| NCBI Accession: | Q9Y5I4.1 |
| UniProt Secondary Accession: | Q9Y5I4,Q2M3V1, Q9Y5F4 |
| UniProt Related Accession: | Q9Y5I4 |
| Molecular Weight: | 96,197 Da |
| NCBI Full Name: | Protocadherin alpha-C2 |
| NCBI Synonym Full Names: | protocadherin alpha subfamily C, 2 |
| NCBI Official Symbol: | PCDHAC2 |
| NCBI Official Synonym Symbols: | PCDH-ALPHA-C2 |
| NCBI Protein Information: | protocadherin alpha-C2 |
| UniProt Protein Name: | Protocadherin alpha-C2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHAC2 |
| UniProt Entry Name: | PCDC2_HUMAN |
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