Antibody Name:	PCDHAC1 Antibody (PACO20184)
Antibody SKU:	PACO20184
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200
Species Reactivity:	Human
Immunogen:	Synthetic peptide of human PCDHAC1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20184(PCDHAC1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: K562 cells, Primary antibody: PACO20184(PCDHAC1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20184(PCDHAC1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene is a member of the protocadherin α gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The α gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences.

Synonyms:

protocadherin α subfamily C, 1

UniProt Protein Function:	PCDHAC1: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneMolecular Function: calcium ion bindingBiological Process: nervous system development; cell adhesion; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:	This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9H158
NCBI GenInfo Identifier:	143811434
NCBI Gene ID:	56135
NCBI Accession:	Q9H158.2
UniProt Secondary Accession:	Q9H158,Q9Y5F5, Q9Y5I5
UniProt Related Accession:	Q9H158
Molecular Weight:
NCBI Full Name:	Protocadherin alpha-C1
NCBI Synonym Full Names:	protocadherin alpha subfamily C, 1
NCBI Official Symbol:	PCDHAC1
NCBI Official Synonym Symbols:	PCDH-ALPHA-C1
NCBI Protein Information:	protocadherin alpha-C1
UniProt Protein Name:	Protocadherin alpha-C1
UniProt Synonym Protein Names:
Protein Family:	Protocadherin
UniProt Gene Name:	PCDHAC1
UniProt Entry Name:	PCDC1_HUMAN