PAX3 Polyclonal Antibody
- SKU:
- CAB21524
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | PAX3 Polyclonal Antibody |
| Product Code: | CAB21524 |
| Reactivity: | Human |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Cellular Location: | Nucleus |
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 341-479 of human PAX3 (NP_852122.1). |
| Sequence: | QSTIP SNPDS SSAYC LPSTR HGFSS YTDSF VPPSG PSNPM NPTIG NGLSP QVMGL LTNHG GVPHQ PQTDY ALSPL TGGLE PTTTV SASCS QRLDH MKSLD SLPTS QSYCP PTYST TGYSM DPVTG YQYGQ YGQSK PWTF |
| Synonyms: | WS1, WS3, CDHS, HUP2, PAX-3 |
| Calculated MW: | 53kDa |
| Observed MW: | Refer to figures |
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