Pax-8 Transcription Factor Activity Assay
- SKU:
- TFAB00149
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- Pax-8
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
Description
| Product Name: | Pax-8 Transcription Factor Activity Assay |
| Product Code: | TFAB00149 |
| Target: | Pax-8 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie Pax-8 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | PAX8: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells. Interacts with WWTR1. Expressed in the excretory system, thyroid gland and Wilms tumors. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q13 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding; DNA binding; transcription factor activity; thyroid-stimulating hormone receptor activity Biological Process: regulation of apoptosis; anatomical structure morphogenesis; inner ear morphogenesis; central nervous system development; transcription, DNA-dependent; ureteric bud branching; positive regulation of transcription, DNA-dependent; thyroid gland development; positive regulation of transcription from RNA polymerase II promoter; mesonephros development; kidney development; pronephros development; urogenital system development Disease: Hypothyroidism, Congenital, Nongoitrous, 2 |
| NCBI Summary: | This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q06710 |
| NCBI GenInfo Identifier: | 215273928 |
| NCBI Gene ID: | 7849 |
| NCBI Accession: | Q06710.2 |
| UniProt Related Accession: | Q06710 |
| Molecular Weight: | 48kDa |
| NCBI Full Name: | Paired box protein Pax-8 |
| NCBI Synonym Full Names: | paired box 8 |
| NCBI Official Symbol: | PAX8 |
| NCBI Protein Information: | paired box protein Pax-8 |
| UniProt Protein Name: | Paired box protein Pax-8 |
| Protein Family: | Paired box protein |
| UniProt Gene Name: | PAX8 |
| UniProt Entry Name: | PAX8_HUMAN |
