Name: PAPPA Antibody (PACO20169)
SKU: PACO20169
Availability: OutOfStock

Antibody Name:	PAPPA Antibody (PACO20169)
Antibody SKU:	PACO20169
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide of human PAPPA

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20169(PAPPA Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20169(PAPPA Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:	This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.
Synonyms:	pregnancy-associated plasma protein A, pappalysin 1

UniProt Protein Function:	PAPPA: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Belongs to the peptidase M43B family.
UniProt Protein Details:	Protein type:EC 3.4.24.79; Secreted; Secreted, signal peptide; Protease Chromosomal Location of Human Ortholog: 9q33.2 Cellular Component: membrane; extracellular region Molecular Function:metallopeptidase activity; zinc ion binding; metalloendopeptidase activity Biological Process: cellular protein metabolic process; female pregnancy; cell differentiation; proteolysis
NCBI Summary:	This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
UniProt Code:	Q13219
NCBI GenInfo Identifier:	223590248
NCBI Gene ID:	5069
NCBI Accession:	Q13219.3
UniProt Related Accession:	Q13219
Molecular Weight:	Predicted MW: 25.9kDaAccurate MW: 33kDa
NCBI Full Name:	Pappalysin-1
NCBI Synonym Full Names:	pappalysin 1
NCBI Official Symbol:	PAPPA
NCBI Official Synonym Symbols:	PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase
NCBI Protein Information:	pappalysin-1
UniProt Protein Name:	Pappalysin-1
UniProt Synonym Protein Names:	Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase; Pregnancy-associated plasma protein A
Protein Family:	Pappalysin
UniProt Gene Name:	PAPPA
UniProt Entry Name:	PAPP1_HUMAN