Pan-Succinyl-K Monoclonal Antibody
- SKU:
- CAB22228
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IP
Description
| Product Name: | Pan-Succinyl-K Monoclonal Antibody |
| Product Code: | CAB22228 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55837 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IP, ELISA |
| Key Applications: | Western blotting, Immunoprecipitation |
| Recommended Dilution: | WB 1:1000-1:5000, IP 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse liver |
The lysine residue in proteins can undergo to many types of PTMs, such as methylation, acetylation, biotinylation, ubiquitination, ubiquitin-like modifications, propionylation and butyrylation, then leading to the remarkable complexity of PTM networks. Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a Lys (K) residue of a protein molecule .it has been shown that the lysine succinylation responses to different physiological conditions and is evolutional conserved .? It has benn identified 2, 565 succinylation sites from 779 proteins and revealed that lysine succinylation have potential impacts on enzymes involved in mitochondrial metabolism including the amino acid degradation, tricarboxylic acid (TCA) cycle and fatty acid metabolism Thelysine succinylation also occurs in histones, suggesting that it may play an important role in regulating chromatin structures and functions as well
| Immunogen: | A synthetic peptide corresponding to a sequence containing succinylated K. |
| Sequence: | Email for sequence |
| Observed MW: | 10kDa-250kDa |
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