pan 14-3-3 Monoclonal Antibody
- SKU:
- CAB23829
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
Description
| Product Name: | pan 14-3-3 Monoclonal Antibody |
| Product Code: | CAB23829 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC59297 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IF/ICC, ELISA |
| Key Applications: | Western blotting, Immunofluorescence |
| Recommended Dilution: | WB 1:1000-1:5000, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Jurkat, HeLa, 293F, NIH/3T3, H-4-11-E |
| Cellular Location: | Cytosol, Melanosome, Extracellular |
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids human 1-100 of human pan 14-3-3 (NP_006817.1). |
| Sequence: | MEKTE LIQKA KLAEQ AERYD DMATC MKAVT EQGAE LSNEE RNLLS VAYKN VVGGR RSAWR VISSI EQKTD TSDKK LQLIK DYREK VESEL RSICT TVLEL |
| Synonyms: | 1C5, HS1, 14-3-3, HS1, GW128, YWHAA, KCIP-1, HEL-S-1, HEL4, YWHAD, KCIP-1, HEL-S-3, POPCHAS, HEL-S-93, 14-3-3-zeta |
| Calculated MW: | 27kDa/28KDa/29KDa |
| Observed MW: | 30kDa |
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