PAIP2 Antibody (PACO40234)
- SKU:
- PACO40234
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PAIP2 Antibody (PACO40234) |
| Antibody SKU: | PACO40234 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Polyadenylate-binding protein-interacting protein 2 protein (1-127AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, SH-SY5Y whole cell lysate, HEK293 whole cell lysate, Mouse lung tissue, Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue. All lanes: PAIP2 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 15 kDa. Observed band size: 15 kDa. |
 | Immunofluorescent analysis of Hela cells using PACO40234 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO40234 at dilution of 1:100. |
| Background: | Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. |
| Synonyms: | Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2), PAIP2, PAIP2A |
| UniProt Protein Function: | PAIP2: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. Interacts with the second and third RRM domains and C- terminus regions of PABPC1 in a 2:1 stoichiometry. Belongs to the PAIP2 family. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: cytoplasm Molecular Function:protein binding; translation repressor activity Biological Process: negative regulation of translational initiation |
| UniProt Code: | Q9BPZ3 |
| NCBI GenInfo Identifier: | 46397013 |
| NCBI Gene ID: | 51247 |
| NCBI Accession: | Q9BPZ3.1 |
| UniProt Secondary Accession: | Q9BPZ3,Q49A06, Q9H0Y5, Q9P0Q8, B2RBI1, D3DQC6, |
| UniProt Related Accession: | Q9BPZ3 |
| Molecular Weight: | 14,984 Da |
| NCBI Full Name: | Polyadenylate-binding protein-interacting protein 2 |
| NCBI Synonym Full Names: | poly(A) binding protein interacting protein 2 |
| NCBI Official Symbol: | PAIP2 |
| NCBI Official Synonym Symbols: | PAIP-2; PAIP2A |
| NCBI Protein Information: | polyadenylate-binding protein-interacting protein 2 |
| UniProt Protein Name: | Polyadenylate-binding protein-interacting protein 2 |
| Protein Family: | Polyadenylate-binding protein-interacting protein |
| UniProt Gene Name: | PAIP2 |
| UniProt Entry Name: | PAIP2_HUMAN |
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