PACS2 Antibody (PACO57908)
- SKU:
- PACO57908
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PACS2 Antibody (PACO57908) |
| Antibody SKU: | PACO57908 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Phosphofurin acid, c cluster sorting protein 2 protein (268-465AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO57908 diluted at 1:400 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO57908 diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acid, c cluster-containing ion channels to distinct subcellular compartments. |
| Synonyms: | Phosphofurin acid, c cluster sorting protein 2 (PACS-2) (PACS1-like protein), PACS2, KIAA0602 PACS1L |
| UniProt Protein Function: | PACS2: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. Belongs to the PACS family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 14q32.33Cellular Component: endoplasmic reticulumBiological Process: autophagic vacuole formation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q86VP3 |
| NCBI GenInfo Identifier: | 117949768 |
| NCBI Gene ID: | 23241 |
| NCBI Accession: | Q86VP3.3 |
| UniProt Secondary Accession: | Q86VP3,O60342, Q6P191, Q96FL7, A2VDJ9, G8JLK3 |
| UniProt Related Accession: | Q86VP3 |
| Molecular Weight: | 89,609 Da |
| NCBI Full Name: | Phosphofurin acidic cluster sorting protein 2 |
| NCBI Synonym Full Names: | phosphofurin acidic cluster sorting protein 2 |
| NCBI Official Symbol: | PACS2 |
| NCBI Official Synonym Symbols: | PACS-2; PACS1L |
| NCBI Protein Information: | phosphofurin acidic cluster sorting protein 2 |
| UniProt Protein Name: | Phosphofurin acidic cluster sorting protein 2 |
| UniProt Synonym Protein Names: | PACS1-like protein |
| Protein Family: | Phosphofurin acidic cluster sorting protein |
| UniProt Gene Name: | PACS2 |
| UniProt Entry Name: | PACS2_HUMAN |
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