PA Antibody (PACO35006)
- SKU:
- PACO35006
- Product Type:
- Antibody
- Reactivity:
- Virus - Influenza A
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | PA Antibody (PACO35006) |
| Antibody SKU: | PACO35006 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Influenza A virus |
| Immunogen: | Recombinant Influenza A virus Polymerase acid, c protein (1-716AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex. |
| Synonyms: | Polymerase acid, c protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2), PA |
| UniProt Protein Function: | Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | A4U6V9 |
| NCBI GenInfo Identifier: | 229891345 |
| NCBI Gene ID: | |
| NCBI Accession: | A4U6V9.1 |
| UniProt Secondary Accession: | A4U6V9 |
| UniProt Related Accession: | A4U6V9 |
| Molecular Weight: | 29,411 Da |
| NCBI Full Name: | Polymerase acidic protein |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Polymerase acidic protein |
| UniProt Synonym Protein Names: | RNA-directed RNA polymerase subunit P2 |
| Protein Family: | Protein |
| UniProt Gene Name: | PA |
| UniProt Entry Name: | PA_I45A0 |
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