p53 Polyclonal Antibody (CAB21630)
- SKU:
- CAB21630
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IF
- Applications:
- IHC
- Applications:
- IP
Description
| Product Name: | p53 Polyclonal Antibody |
| Product Code: | CAB21630 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunofluorescence, Immunohistochemistry, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunofluorescence, Immunohistochemistry, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IF/ICC 1:50-1:200, IHC-P 1:50-1:200, IP 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body |
This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 290-390 of mouse p53 (NP_035770.2). |
| Sequence: | EVLCP ELPPG SAKRA LPTCT SASPP QKKKP LDGEY FTLKI RGRKR FEMFR ELNEA LELKD AHATE ESGDS RAHSS YLKTK KGQST SRHKK TMVKK VGPDS D |
| Synonyms: | bbl, bfy, bhy, p44, p53, Tp53 |
| Calculated MW: | 43kDa |
| Observed MW: | Refer to figures |
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