p53 Polyclonal Antibody (CAB21629)
- SKU:
- CAB21629
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Applications:
- IP
Description
| Product Name: | p53 Polyclonal Antibody |
| Product Code: | CAB21629 |
| Reactivity: | Human |
| Applications: | Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, IHC-P, IF/ICC, IP, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry, Immunofluorescence, Immunoprecipitation |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:100-1:500, IF/ICC 1:50-1:200, IP 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | 293T |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum, Mitochondrion matrix, Nucleus, PML body |
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-393 of human p53. (NP_000537.3). |
| Sequence: | MEEPQ SDPSV EPPLS QETFS DLWKL LPENN VLSPL PSQAM DDLML SPDDI EQWFT EDPGP DEAPR MPEAA PPVAP APAAP TPAAP APAPS WPLSS SVPSQ KTYQG SYGFR LGFLH SGTAK SVTCT YSPAL NKMFC QLAKT CPVQL WVDST PPPGT RVRAM AIYKQ SQHMT EVVRR CPHHE RCSDS DGLAP PQHLI RVEGN LRVEY LDDRN TFRHS VVVPY EPPEV GSDCT TIHYN YMCNS SCMGG MNRRP ILTII TLEDS SGNLL GRNSF EVRVC ACPGR DRRTE EENLR KKGEP HHELP PGSTK RALPN NTSSS PQPKK KPLDG EYFTL QIRGR ERFEM FRELN EALEL KDAQA GKEPG GSRAH SSHLK SKKGQ STSRH KKLMF KTEGP DSD |
| Synonyms: | P53, BCC7, LFS1, BMFS5, TRP53 |
| Calculated MW: | 44kDa |
| Observed MW: | 53kDa |
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