p44/42 MAPK (Erk1/2) Monoclonal Antibody
- SKU:
- CAB22447
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | p44/42 MAPK (Erk1/2) Monoclonal Antibody |
| Product Code: | CAB22447 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC51163 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:1000-1:5000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, 293T, NIH/3T3, Mouse brain, C6 |
| Cellular Location: | Cytoplasm, cytoskeleton, spindle, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm , Membrane, caveola, Cell junction, focal adhesion |
| Customer Validation: | WB(Homo sapiens, Mus musculus ) |
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ERK1/2ERK1/2 (NP_002737.2/NP_002736.3). |
| Sequence: | FLTEY VATRW YRAPE IMLNS KGYTK SIDIW SVGCI LAEML SNRPI FPGKH YLDQL NHILG ILGSP SQEDL NCIIN MKARN YLQSL PSKTK VAWAK LFPKS D/LNS KGYTK SIDIW SVGCI LAEML SNRPI FPGKH YLDQL NHILG ILGSP SQEDL NCIIN LKARN YLLSL PHKNK VPWNR LFPNA DSKAL DLLDK MLTFN PHK |
| Synonyms: | ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK, 5594/5595 |
| Calculated MW: | 42, 44kDa |
| Observed MW: | 42, 44kDa |
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