Antibody Name:	Outer capsid glycoprotein VP7 Antibody (PACO34126)
Antibody SKU:	PACO34126
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Rotavirus A
Immunogen:	Recombinant Rotavirus A Outer capsid glycoprotein VP7 protein (51-326AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

Calcium-binding protein that interacts with rotavirus cell receptors once the initial attachment by VP4 has been achieved. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. Following entry into the host cell, low intracellular or intravesicular Ca2+ concentration probably causes the calcium-stabilized VP7 trimers to dissociate from the virion. This step is probably necessary for the membrane-disrupting entry step and the release of VP4, which is locked onto the virion by VP7.

Synonyms:

Outer capsid glycoprotein VP7

UniProt Protein Function:	Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In integrin-dependent strains, VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage, once the initial attachment by VP4 has been achieved ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:	P10501
NCBI GenInfo Identifier:	226693575
NCBI Gene ID:
NCBI Accession:	P10501.2
UniProt Secondary Accession:	P10501,B3SRX1
UniProt Related Accession:	P10501
Molecular Weight:	33,719 Da
NCBI Full Name:	Outer capsid glycoprotein VP7
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:	Outer capsid glycoprotein VP7
UniProt Synonym Protein Names:
Protein Family:
UniProt Gene Name:
UniProt Entry Name:	VP7_ROTHT