OTUB1 Monoclonal Antibody [PAT17E10AT] (CPAB0643)
![OTUB1 Monoclonal Antibody [PAT17E10AT] (CPAB0643)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58863/64045/otub1-monoclonal-antibody-pat17e10at-cpab0643__40482__27846.1706535241.jpg?c=1 "OTUB1 Monoclonal Antibody [PAT17E10AT] (CPAB0643)")
- SKU:
- CPAB0643
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- PAT17E10AT
- Applications:
- WB
- Applications:
- ELISA
- Applications:
- FC
![OTUB1 Monoclonal Antibody [PAT17E10AT] (CPAB0643)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58863/64045/otub1-monoclonal-antibody-pat17e10at-cpab0643__40482__27846.1706535241.jpg?c=1&imbypass=on "OTUB1 Monoclonal Antibody [PAT17E10AT] (CPAB0643)")
Description
system_update_alt Datasheet
| Product Name: | OTUB1 Antibody |
| Product Sku: | CPAB0643 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human OTUB1 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human OTUB1 protein 1-271 amino acids purified from Ecoli. |
| Clone: | PAT17E10AT. |
| Reactivity: | Other bodies |
| Applications: | Western Blot, ELISA, Flow Cytometry |
| Purification Method: | OTUB1 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography. |
| Isotype: | IgG1 |
| Background: | Otubain 1 (OTUB1) belongs to the ovarian tumor (OUT) superfamily of predicted cysteine proteases and inhibits cytokine gene transcription in the immune system through its interaction with a ubiquitin protease and E3 ubiquitin ligase. OTUB1 is a highly specific ubiquitin iso-peptidase, it cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. OTUB1 is believed to work in specific ubiquitin-dependent pathways, possibly by providing an editing function of polyubiquitin chain growth. OTUB1 is a hydrolase that removes conjugated ubiquitin from proteins in vitro and may therefore have a significant regulatory role in the level of protein turnover by preventing degradation. Additionally, OTUB1 is a regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered impassive to antigen re-challenge and no longer respond to their cognate antigen. OTUB1 acts via its interaction with RNF128/GRAIL, which is an essential inductor of CD4 T-cell anergy. |
| Synonyms: | Ubiquitin thioesterase OTUB1, Otubain-1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Ubiquitin-specific-processing protease OTUB1, Deubiquitinating enzyme OTUB1, OTUB1, OTB1, OTU1, HSPC263, MGC4584, FLJ20113, FLJ40710, MGC111158. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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