OSCAR Antibody (PACO64431)
- SKU:
- PACO64431
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | OSCAR Antibody (PACO64431) |
| Antibody SKU: | PACO64431 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:1000-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Peptide sequence from Human Osteoclast-associated immunoglobulin-like receptor protein (265-279AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: THP-1 whole cell lysate, HL60 whole cell lysate. All lanes: OSCAR antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 31, 29, 30, 28 kDa. Observed band size: 31 kDa. |
| Background: | Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. |
| Synonyms: | Osteoclast-associated immunoglobulin-like receptor (Osteoclast-associated receptor) (hOSCAR) (Polymeric immunoglobulin receptor 3) (PIgR-3) (PIgR3) (Poly-Ig receptor 3), OSCAR |
| UniProt Protein Function: | OSCAR: Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Chromosomal Location of Human Ortholog: 19q13.42Cellular Component: plasma membrane; integral to membrane |
| UniProt Protein Details: | |
| NCBI Summary: | Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q8IYS5 |
| NCBI GenInfo Identifier: | 311033418 |
| NCBI Gene ID: | 126014 |
| NCBI Accession: | Q8IYS5.3 |
| UniProt Secondary Accession: | Q8IYS5,Q5GRG5, Q8N763, Q8NHL4, Q8WXQ0, Q8WXQ1, Q8WXQ2 B7WNS2 |
| UniProt Related Accession: | Q8IYS5 |
| Molecular Weight: | 30,481 Da |
| NCBI Full Name: | Osteoclast-associated immunoglobulin-like receptor |
| NCBI Synonym Full Names: | osteoclast associated, immunoglobulin-like receptor |
| NCBI Official Symbol: | OSCAR |
| NCBI Official Synonym Symbols: | PIGR3; PIgR-3 |
| NCBI Protein Information: | osteoclast-associated immunoglobulin-like receptor; poly-Ig receptor 3; polymeric immunoglobulin receptor 3; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2 |
| UniProt Protein Name: | Osteoclast-associated immunoglobulin-like receptor |
| UniProt Synonym Protein Names: | Polymeric immunoglobulin receptor 3 |
| Protein Family: | Protein |
| UniProt Gene Name: | OSCAR |
| UniProt Entry Name: | OSCAR_HUMAN |
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