OPN1SW Antibody (PACO54358)
- SKU:
- PACO54358
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | OPN1SW Antibody (PACO54358) |
| Antibody SKU: | PACO54358 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Short-wave-sensitive opsin 1 protein (307-348AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: U87 whole cell lysate. All lanes: OPN1SW antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40 kDa. Observed band size: 40 kDa. |
 | Immunofluorescence staining of U251 cells with PACO54358 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. |
| Synonyms: | Short-wave-sensitive opsin 1 (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP), OPN1SW, BCP |
| UniProt Protein Function: | OPN1SW: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Defects in OPN1SW are the cause of tritan color blindness (CBT). Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1Chromosomal Location of Human Ortholog: 7q32.1Cellular Component: integral to plasma membraneMolecular Function: G-protein coupled receptor activity; photoreceptor activity; receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; phototransduction, visible light; visual perception; phototransduction; retinoid metabolic process; signal transduction; protein-chromophore linkageDisease: Tritanopia |
| UniProt Protein Details: | |
| NCBI Summary: | This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P03999 |
| NCBI GenInfo Identifier: | 4502387 |
| NCBI Gene ID: | 611 |
| NCBI Accession: | NP_001699.1 |
| UniProt Secondary Accession: | P03999,Q13877 |
| UniProt Related Accession: | P03999 |
| Molecular Weight: | 39,135 Da |
| NCBI Full Name: | short-wave-sensitive opsin 1 |
| NCBI Synonym Full Names: | opsin 1 (cone pigments), short-wave-sensitive |
| NCBI Official Symbol: | OPN1SW |
| NCBI Official Synonym Symbols: | BCP; BOP; CBT |
| NCBI Protein Information: | short-wave-sensitive opsin 1; blue-sensitive opsin; blue cone photoreceptor pigment |
| UniProt Protein Name: | Short-wave-sensitive opsin 1 |
| UniProt Synonym Protein Names: | Blue cone photoreceptor pigment; Blue-sensitive opsin; BOP |
| Protein Family: | Probable aspartic-type endopeptidase |
| UniProt Gene Name: | OPN1SW |
| UniProt Entry Name: | OPSB_HUMAN |
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