OPN1MW Antibody (PACO59824)
- SKU:
- PACO59824
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | OPN1MW Antibody (PACO59824) |
| Antibody SKU: | PACO59824 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Medium-wave-sensitive opsin 1 protein (1-52AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: MCF-7 whole cell lysate. All lanes: OPN1MW antibody at 3.2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 41 kDa. Observed band size: 41 kDa. |
 | Immunofluorescence staining of HepG2 cells with PACO59824 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. |
| Synonyms: | Medium-wave-sensitive opsin 1 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP), OPN1MW, GCP |
| UniProt Protein Function: | OPN1MW: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD); also known as deuteranopia. Defects in OPN1MW are a cause of blue cone monochromacy (BCM). A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia. Defects in OPN1MW are a cause of cone dystrophy type 5 (COD5). A X-linked cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1Chromosomal Location of Human Ortholog: Xq28Cellular Component: integral to plasma membrane; photoreceptor outer segment; plasma membraneMolecular Function: G-protein coupled photoreceptor activity; photoreceptor activityBiological Process: G-protein coupled receptor protein signaling pathway; phototransduction; positive regulation of cytokinesis; retinoid metabolic processDisease: Blue Cone Monochromacy; Colorblindness, Partial, Deutan Series |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P04001 |
| NCBI GenInfo Identifier: | 129215 |
| NCBI Gene ID: | 2652 |
| NCBI Accession: | P04001.1 |
| UniProt Secondary Accession: | P04001 |
| UniProt Related Accession: | P04001 |
| Molecular Weight: | 40,584 Da |
| NCBI Full Name: | Medium-wave-sensitive opsin 1 |
| NCBI Synonym Full Names: | opsin 1 (cone pigments), medium-wave-sensitive |
| NCBI Official Symbol: | OPN1MW |
| NCBI Official Synonym Symbols: | CBD; GCP; GOP; CBBM; COD5; OPN1MW1 |
| NCBI Protein Information: | medium-wave-sensitive opsin 1 |
| UniProt Protein Name: | Medium-wave-sensitive opsin 1 |
| UniProt Synonym Protein Names: | Green cone photoreceptor pigment; Green-sensitive opsin; GOP |
| Protein Family: | Medium-wave-sensitive opsin |
| UniProt Gene Name: | OPN1MW |
| UniProt Entry Name: | OPSG_HUMAN |
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