OLFM3 Antibody (PACO16812)
- SKU:
- PACO16812
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | OLFM3 Antibody (PACO16812) |
| Antibody SKU: | PACO16812 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein of human OLFM3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse intestines tissue, Primary antibody: PACO16812(OLFM3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
| Background: | OLFM3 (olfactomedin 3), also known as NOE3, is a 478 amino acid, protein that interacts with myocilin. Myocilin is an extracellular protein that plays a key role in the actomyosin system and is responsible for controlling intraocular pressure. OLFM3 is a secreted protein that contains an olfactomedin-like (OLF) domain, an approximately 260 amino acid, motif commonly found in secreted glycoproteins. OLFM3 localizes to the Golgi apparatus of the cell and is highly expressed in both eye and brain tissue. Mutations in the gene that encodes OLFM3 may cause severe glaucoma, a condition in which increased intraocular pressure within the eyeball causes loss of eye sight. |
| Synonyms: | olfactomedin 3 |
| UniProt Protein Function: | OLFM3: 6 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 1p22Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96PB7 |
| NCBI GenInfo Identifier: | 20139068 |
| NCBI Gene ID: | 118427 |
| NCBI Accession: | Q96PB7.1 |
| UniProt Secondary Accession: | Q96PB7,Q5T3V6, Q6IMI7, Q6IMI8, Q6IMI9, Q6IMJ1, Q8TBG1 Q96PB2, Q96PB3, Q96PB4 |
| UniProt Related Accession: | Q96PB7 |
| Molecular Weight: | 16,790 Da |
| NCBI Full Name: | Noelin-3 |
| NCBI Synonym Full Names: | olfactomedin 3 |
| NCBI Official Symbol: | OLFM3 |
| NCBI Official Synonym Symbols: | NOE3; NOELIN3; OPTIMEDIN |
| NCBI Protein Information: | noelin-3 |
| UniProt Protein Name: | Noelin-3 |
| UniProt Synonym Protein Names: | Olfactomedin-3; Optimedin |
| Protein Family: | Noelin |
| UniProt Gene Name: | OLFM3 |
| UniProt Entry Name: | NOE3_HUMAN |
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