OGDH Monoclonal Antibody
- SKU:
- CAB22163
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | OGDH Monoclonal Antibody |
| Product Code: | CAB22163 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC55379 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | HeLa, MCF7, Mouse heart, Mouse skeletal muscle, Rat heart |
| Cellular Location: | Mitochondrion, Nucleus |
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 869-1023 of human OGDH (NP_002532.2). |
| Sequence: | RSSFD EMLPG THFQR VIPED GPAAQ NPENV KRLLF CTGKV YYDLT RERKA RDMVG QVAIT RIEQL SPFPF DLLLK EVQKY PNAEL AWCQE EHKNQ GYYDY VKPRL RTTIS RAKPV WYAGR DPAAA PATGN KKTHL TELQR LLDTA FDLDV FKNFS |
| Synonyms: | E1k, E1o, KGD1, OGDC, AKGDH, OGDH2, OGDHD, OGDH-E1 |
| Calculated MW: | 116kDa |
| Observed MW: | 116kDa |
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