OCRL Polyclonal Antibody
- SKU:
- CAB21519
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | OCRL Polyclonal Antibody |
| Product Code: | CAB21519 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Cellular Location: | Cell projection, Cytoplasmic vesicle, Early endosome membrane, Endosome, Golgi apparatus, Membrane, cilium, clathrin-coated pit, phagosome membrane, photoreceptor outer segment, trans-Golgi network |
This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human OCRL (NP_001578.2). |
| Sequence: | MEPPL PVGAQ PLATV EGMEM KGPLR EPCAL TLAQR NGQYE LIIQL HEKEQ HVQDI IPINS HFRCV QEAEE TLLID IASNS GCKIR VQGDW IRERR FEIPD EEHCL KFLSA VLAAQ KAQSQ LLVPE QKDSS SWYQK LDTKD KPSVF SGLLG FEDNF SSMNL DKKIN SQNQP TGIHR EPPPP PFSVN KMLPR EKEAS NKEQP KVTNT MRKLF VPNTQ SGQRE |
| Synonyms: | LOCR, DENT2, NPHL2, OCRL1, Dent-2, INPP5F, OCRL-1 |
| Calculated MW: | 104kDa |
| Observed MW: | Refer to figures |
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