OAZ3 Antibody (PACO28694)
- SKU:
- PACO28694
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | OAZ3 Antibody (PACO28694) |
| Antibody SKU: | PACO28694 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Ornithine decarboxylase antizyme 3 protein (1-190AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to ODC1 without promoting its degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. |
| Synonyms: | Ornithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3), OAZ3 |
| UniProt Protein Function: | OAZ3: Binds to, and destabilizes, ornithine decarboxylase. Does not accelerate ornithine decarboxylase degeneration. OAZ3 probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells. Belongs to the ODC antizyme family. 1 isoforms of the human protein are produced by ribosomal frameshifting.Protein type: InhibitorChromosomal Location of Human Ortholog: 1q21.3Cellular Component: cytosol; nucleusMolecular Function: protein binding; putrescine transmembrane transporter activity; ornithine decarboxylase inhibitor activityBiological Process: polyamine biosynthetic process; negative regulation of catalytic activity; positive regulation of protein catabolic process; spermatogenesis; regulation of phosphoprotein phosphatase activity; regulation of amino acid metabolic process; putrescine transport |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake, however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies in mice showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. Alternatively spliced transcript variants encoding different isoforms, including one resulting from the use of non-AUG (CUG) translation initiation codon, have been found for this gene. [provided by RefSeq, Aug 2014] |
| UniProt Code: | Q9UMX2 |
| NCBI GenInfo Identifier: | 201023343 |
| NCBI Gene ID: | 51686 |
| NCBI Accession: | NP_001128411.1 |
| UniProt Secondary Accession: | Q9UMX2,Q6GMR0, E7EUE7 |
| UniProt Related Accession: | Q9UMX2 |
| Molecular Weight: | |
| NCBI Full Name: | ornithine decarboxylase antizyme 3 isoform 2 |
| NCBI Synonym Full Names: | ornithine decarboxylase antizyme 3 |
| NCBI Official Symbol: | OAZ3 |
| NCBI Official Synonym Symbols: | AZ3; OAZ-t; TISP15 |
| NCBI Protein Information: | ornithine decarboxylase antizyme 3; ODC-Az 3 |
| UniProt Protein Name: | Ornithine decarboxylase antizyme 3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ornithine decarboxylase antizyme |
| UniProt Gene Name: | OAZ3 |
| UniProt Entry Name: | OAZ3_HUMAN |
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