OAT Monoclonal Antibody (CPAB0098)
- SKU:
- CPAB0098
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1
- Applications:
- WB
- Applications:
- IF
- Applications:
- ELISA
Description
system_update_alt Datasheet
| Product Name: | OAT Antibody |
| Product Sku: | CPAB0098 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human OAT mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human OAT amino acids 33-439 purified from Ecoli. |
| Clone: | |
| Reactivity: | Human |
| Applications: | Western Blot, Immunofluorescence, ELISA |
| Purification Method: | OAT antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG1 |
| Background: | Ornithine aminotransferase is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Ornithine aminotransferase (OAT) is a 49kDa nucleus-encoded protein imported into mitochondria to give the mature 48kDa OAT polypeptide. It is found in humans, animals, insects, plants and microorganisms. The OAT has a sex-differential expression in the mouse kidney. OAT plays central physiological roles in amino acid metabolism. OAT shows a large structural and mechanistic similarity to other enzymes from the subgroup III of aminotransferases that transfer an amino group from a carbon atom which doesnt carry a carboxyl function. OAT is vital for nitrogen recycling from arginine but not for the stress-induced proline accumulation. OAT enzyme deficiency causes the autosomal recessive eye disease Gyrate Atrophy. |
| Synonyms: | Ornithine aminotransferase mitochondrial, Ornithine delta-aminotransferase, Ornithine-oxo-acid aminotransferase, OAT, OKT, GACR, HOGA, OATASE, DKFZp781A11155. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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