Description
Antibody Name: | OASL Antibody (PACO14794) |
Antibody SKU: | PACO14794 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
Species Reactivity: | Human |
Immunogen: | Fusion protein of human OASL |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14794(OASL Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200). |
Background: | OASL encodes an interferon-induced protein that is a member of the 2-5A synthetase family. 2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, resulting in general RNA degradation and consequent inhibition of protein synthesis. 2-5As are produced by a well-conserved family of interferon-induced enzymes, the 2-5A synthetases or OASs |
Synonyms: | 2'-5'-oligoadenylate synthetase-like |
UniProt Protein Function: | OASL: a protein of the 2'-5'-oligoadenylate synthetase family, but does not have 2'-5'-OAS activity. Binds double-stranded RNA and DNA. Interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Contains a ubiquitin-like domain that interacts with methyl CpG-binding protein 1. |
UniProt Protein Details: | Protein type:DNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoplasm; cytosol; membrane; nucleolus; nucleoplasm Molecular Function:2'-5'-oligoadenylate synthetase activity; DNA binding; double-stranded RNA binding; RNA binding; thyroid hormone receptor binding Biological Process: negative regulation of viral genome replication; response to virus |
UniProt Code: | Q15646 |
NCBI GenInfo Identifier: | 6226835 |
NCBI Gene ID: | 8638 |
NCBI Accession: | Q15646.2 |
UniProt Secondary Accession: | Q15646,O75686, Q17R95, Q9Y6K6, Q9Y6K7, B2RAZ2, I1YDD2 |
UniProt Related Accession: | Q15646 |
Molecular Weight: | 59kDa |
NCBI Full Name: | 2'-5'-oligoadenylate synthase-like protein |
NCBI Synonym Full Names: | 2'-5'-oligoadenylate synthetase like |
NCBI Official Symbol: | OASL |
NCBI Official Synonym Symbols: | OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL |
NCBI Protein Information: | 2'-5'-oligoadenylate synthase-like protein |
UniProt Protein Name: | 2'-5'-oligoadenylate synthase-like protein |
UniProt Synonym Protein Names: | 2'-5'-OAS-related protein; 2'-5'-OAS-RP; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL |
Protein Family: | 2'-5'-oligoadenylate synthase-like protein |
UniProt Gene Name: | OASL |