Name: OASL Antibody (PACO14794)
SKU: PACO14794
Availability: OutOfStock

Antibody Name:	OASL Antibody (PACO14794)
Antibody SKU:	PACO14794
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:	Human
Immunogen:	Fusion protein of human OASL

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14794(OASL Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: x200).

Background:	OASL encodes an interferon-induced protein that is a member of the 2-5A synthetase family. 2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, resulting in general RNA degradation and consequent inhibition of protein synthesis. 2-5As are produced by a well-conserved family of interferon-induced enzymes, the 2-5A synthetases or OASs
Synonyms:	2'-5'-oligoadenylate synthetase-like

UniProt Protein Function:	OASL: a protein of the 2'-5'-oligoadenylate synthetase family, but does not have 2'-5'-OAS activity. Binds double-stranded RNA and DNA. Interacts with the ligand binding domain of the thyroid receptor (TR). Does not require the presence of thyroid hormone for its interaction. Contains a ubiquitin-like domain that interacts with methyl CpG-binding protein 1.
UniProt Protein Details:	Protein type:DNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: cytoplasm; cytosol; membrane; nucleolus; nucleoplasm Molecular Function:2'-5'-oligoadenylate synthetase activity; DNA binding; double-stranded RNA binding; RNA binding; thyroid hormone receptor binding Biological Process: negative regulation of viral genome replication; response to virus
UniProt Code:	Q15646
NCBI GenInfo Identifier:	6226835
NCBI Gene ID:	8638
NCBI Accession:	Q15646.2
UniProt Secondary Accession:	Q15646,O75686, Q17R95, Q9Y6K6, Q9Y6K7, B2RAZ2, I1YDD2
UniProt Related Accession:	Q15646
Molecular Weight:	59kDa
NCBI Full Name:	2'-5'-oligoadenylate synthase-like protein
NCBI Synonym Full Names:	2'-5'-oligoadenylate synthetase like
NCBI Official Symbol:	OASL
NCBI Official Synonym Symbols:	OASLd; TRIP14; TRIP-14; p59OASL; p59 OASL; p59-OASL
NCBI Protein Information:	2'-5'-oligoadenylate synthase-like protein
UniProt Protein Name:	2'-5'-oligoadenylate synthase-like protein
UniProt Synonym Protein Names:	2'-5'-OAS-related protein; 2'-5'-OAS-RP; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; p59 OASL; p59OASL
Protein Family:	2'-5'-oligoadenylate synthase-like protein
UniProt Gene Name:	OASL