Description
Antibody Name: | NXF3 Antibody (PACO28682) |
Antibody SKU: | PACO28682 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Nuclear RNA export factor 3 protein (1-531AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human heart tissue using PACO28682 at dilution of 1:100. |
![]() | Immunofluorescent analysis of MCF-7 cells using PACO28682 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | May function as a tissue-specific nuclear mRNA export factor. |
Synonyms: | Nuclear RNA export factor 3 (TAP-like protein 3) (TAPL-3), NXF3, TAPL3 |
UniProt Protein Function: | NXF3: May function as a tissue-specific nuclear mRNA export factor. Belongs to the NXF family.Chromosomal Location of Human Ortholog: Xq22Cellular Component: cytoplasm; nuclear RNA export factor complex; nucleoplasm; nucleusMolecular Function: mRNA binding; nucleotide binding; protein bindingBiological Process: mRNA export from nucleus; poly(A)+ mRNA export from nucleus |
UniProt Protein Details: | |
NCBI Summary: | This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H4D5 |
NCBI GenInfo Identifier: | 20455187 |
NCBI Gene ID: | 56000 |
NCBI Accession: | Q9H4D5.1 |
UniProt Secondary Accession: | Q9H4D5,Q5H9I1, Q9H1A9, B4DYS7 |
UniProt Related Accession: | Q9H4D5 |
Molecular Weight: | 26,653 Da |
NCBI Full Name: | Nuclear RNA export factor 3 |
NCBI Synonym Full Names: | nuclear RNA export factor 3 |
NCBI Official Symbol: | NXF3 |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | nuclear RNA export factor 3 |
UniProt Protein Name: | Nuclear RNA export factor 3 |
UniProt Synonym Protein Names: | TAP-like protein 3; TAPL-3 |
Protein Family: | Nuclear RNA export factor |
UniProt Gene Name: | NXF3 |
UniProt Entry Name: | NXF3_HUMAN |